So I also had this problem and I also did a lot of investigation and trial and error.
For the application load balancer I use a HTTP client keep alive duration: 3600 seconds. Very long I know. Somehow it seems to help. Also a Connection idle timeout: 900 seconds.
For the nginx proxy configuration I use the following:
proxy_connect_timeout 600s;
proxy_read_timeout 900s;
proxy_send_timeout 900s;
proxy_set_header Connection $connection_upgrade;
proxy_set_header Upgrade $http_upgrade;
proxy_set_header Host $host;
proxy_set_header X-Real-IP $remote_addr;
proxy_set_header X-Forwarded-For $proxy_add_x_forwarded_for;
proxy_redirect off;
I didn’t run into this problem now for quite some time, so it looks like this helps. Also I use newest Jmix (almost) 2.1.3